What is the difference between 5-Amino-1MQ and Humanin?

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is graded C+ and is Not FDA-approved — small-molecule research compound (NNMT inhibitor). Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — 5-Amino-1MQ or Humanin?

On our internal evidence scale, 5-Amino-1MQ is C+ and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of 5-Amino-1MQ vs Humanin?

5-Amino-1MQ: 50–150 mg orally daily (research-only). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

5-Amino-1MQ vs Humanin

Both 5-Amino-1MQ and Humanin are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

5-Amino-1MQ

Evidence C+

5-Amino-1-Methylquinolinium

A small-molecule NNMT inhibitor that has produced fat loss and improved muscle stem-cell function in obese rodents. No human RCTs yet.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	5-Amino-1MQ	Humanin
Evidence Grade	C+	B
FDA Status	Not FDA-approved — small-molecule research compound (NNMT inhibitor)	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	50–150 mg orally daily (research-only)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	31	5
Categories	fat-loss, longevity	mitochondrial, longevity, neuroprotection

Key reported benefits — 5-Amino-1MQ

✓NNMT inhibition
✓Fat-mass reduction (preclinical)
✓Muscle stem-cell support

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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