What is the difference between 5-Amino-1MQ and Glutathione (GSH)?

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is graded C+ and is Not FDA-approved — small-molecule research compound (NNMT inhibitor). Glutathione (GSH) (Reduced L-Glutathione) is graded B and is Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — 5-Amino-1MQ or Glutathione (GSH)?

On our internal evidence scale, 5-Amino-1MQ is C+ and Glutathione (GSH) is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of 5-Amino-1MQ vs Glutathione (GSH)?

5-Amino-1MQ: 50–150 mg orally daily (research-only). Glutathione (GSH): 200–600 mg sublingual / 600–2400 mg IV (compounded). Always work with a licensed clinician — peptide dosing should be individualized.

5-Amino-1MQ vs Glutathione (GSH)

Both 5-Amino-1MQ and Glutathione (GSH) are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

5-Amino-1MQ

Evidence C+

5-Amino-1-Methylquinolinium

A small-molecule NNMT inhibitor that has produced fat loss and improved muscle stem-cell function in obese rodents. No human RCTs yet.

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Glutathione (GSH)

Evidence B

Reduced L-Glutathione

Technically a tripeptide (γ-glutamyl-cysteinyl-glycine) and the body's primary antioxidant. Often grouped with peptide therapy in IV/compounded form for liver support and oxidative stress.

View full Glutathione (GSH) profile →

Side-by-Side

Attribute	5-Amino-1MQ	Glutathione (GSH)
Evidence Grade	C+	B
FDA Status	Not FDA-approved — small-molecule research compound (NNMT inhibitor)	Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded
Typical Dose	50–150 mg orally daily (research-only)	200–600 mg sublingual / 600–2400 mg IV (compounded)
Clinics Indexed	31	312
Categories	fat-loss, longevity	antioxidant, longevity

Key reported benefits — 5-Amino-1MQ

✓NNMT inhibition
✓Fat-mass reduction (preclinical)
✓Muscle stem-cell support

Key reported benefits — Glutathione (GSH)

✓Master antioxidant
✓Liver detoxification support
✓Oxidative stress reduction

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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